Trigger Shots For Infertility: Importance And Procedure

Published by Dr. Subha on

Artificial insemination at home_ how to use a syringe to get pregnant

Many couples who try to get pregnant but in vain often do not consider that they are not getting the desired result due to a fertility problem. There are several reasons why a couple cannot have a child, but infertility is the main cause. Fertility problems can make conception very difficult, but there is no need to lose hope if you have faith in medical science. Advances in the field of medicine have improved fertility. Trigger shots for infertility, which are part of fertility-enhancing techniques and medications, are commonly used by doctors to increase the chances of getting pregnant. 

If you have been trying to conceive for more than a year, you may consider this option, but before that, you need to learn everything there is to know about trigger shots.

What are the trigger shots?

A trigger shot is a shot of hormones that signal the ovaries to mature and release eggs. The shots contain human chorionic gonadotropin (hCG) that sends a trigger to the ovary to mature and release an egg. 

The shots start the maturation process of an egg to help it be able to fertilize itself. The maturation of an egg is called meiosis. During this process, an egg sheds about 23 or half of the 46 chromosomes. 

A trigger shot is used in two cases: the first is used to time intrauterine insemination (IUI) and the second is used as part of an in vitro fertilization (IVF) process to prepare for the egg retrieval procedure. The trigger shot is also called the hCG trigger shot.

What is The need for a trigger shot for fertility?

A trigger shot is needed for the eggs to be ready to mature for harvest. During IVF, trigger injections for fertility activate the ovaries in a developmental cycle. This allows the fertility team that is monitoring your treatment to collect the eggs at a specific time. 

When to take a trigger shot?

Your doctor will be able to better guide you on when to give trigger injections for fertility. Everything will be controlled with the development of the ovarian follicles (which should grow to an optimal size) and it is important to follow the routine since any change could cause a delay in your treatment. Trigger shots are recommended in the following cases:

  • If you suffer from ovulatory infertility
  • In case you have been diagnosed with unexplained infertility
  • As part of the IVF treatment procedure, regardless of the reason for infertility

Ovidrel is a common fertility drug that triggers and improves the chances of ovulation. Ovidrel injections are an injectable medication that can be used as a trigger shot during IUI, a scheduled in vitro fertilization intercourse. 

FERTILITY COUNSELLING FOR HOME IUI with v conceive home insemination kit

Ovidrel is used alone but also with other fertility drugs as listed below:

  • It is often used with Clomid, which is another fertility drug.
  • It is often used with gonadotropins.

How to perform trigger shots?

The triggers are made from recombinant human chorionic gonadotropin (r-HCG). This is done in the laboratory using DNA technology. 

The hormone is similar to the body’s natural luteinizing hormone (LH) that triggers ovulation during the menstrual cycle. Most doctors administer trigger injections for fertility. But one can administer shots on his own. In case you have to do it yourself, you can follow the guide below on how to give hCG shots:


Things you will need:

  • Ovidrel prefilled insemination syringe.
  • Alcohol swabs and gauze pads for medical use.
  • A safe container to dispose of used needles.

How to give the shots?

  • Begin by placing the supplies on a flat, clean, dry surface.
  • Wash your hands with soap and warm water for at least 45 seconds. Dry with a clean towel.
  • Take the Ovidrel prefilled insemination syringe out of the box.
  • Point the needle upward and remove the safety cap.
  • Tap the insemination syringe lightly to remove trapped air bubbles while still pointing the needle upward.
  • Push the plunger to remove excess air until you can see small drops of medicine at the tip of the needle.
  • Choose a place on the abdomen a couple of inches from the belly button to inject the medicine.
  • Disinfect the area where the shots are to be given with an alcohol swab. Let it dry.
  • Now carefully hold the Ovidrel needle with one hand and one finger on the plunger. The remaining three fingers should hold the container. Use your other hand to pinch a generous amount of fatty tissue in a crease around your abdomen to insert the needle.
  • Slowly insert the full needle into the area at a 45 or 90-degree angle.
  • Once the needle is attached, leave the skin on and insert the Ovidrel insemination syringe by gently pressing down on the plunger until all of the medicine is injected.
  • Once the medicine is inserted, gradually release the needle from your abdomen. Apply gauze to the area to prevent bleeding.
  • Now put the needle in a container and discard it.

How does a trigger shot work?

The timing and administration of a trigger shot depend entirely on how it is being used. Ovidrel is generally timed and administered according to the fertility treatment protocol. 

Ovidrel is a subcutaneous shot that comes in a pre-filled device that is ready to be injected. It is a liquid that is injected into the fatty tissue just under the skin. When administered, hCG causes the eggs to go through a final growth spurt and ovulate.

One must take care and caution to follow the doctor’s instructions for trigger shots for infertility. Even a few hours late can cause problems or problems in treatment.

Trigger shot side effects

In addition to experiencing some discomfort at the site of the shot, trigger shots can cause the following side effects:

  • Stomach-ache
  • Pain in the abdomen
  • Vomiting or nausea
  • Bruising or pain at the site of the shot

The use of fertility drugs can also increase the chances of developing ovarian hyperstimulation syndrome (OHSS). When Ovidrel is used as part of IVF, one in three women is likely to experience adverse effects. OHSS is more common when Ovidrel is used with gonadotropins.

What happens if you lose your trigger shot?

If you miss a trigger shots, it is important to inform your doctor about the same. Your doctor will be able to guide you in the best way if such a situation arises. An egg cannot be retrieved once the ovary has released it, so the medical team is aware of the situation to put the necessary things to correct the situation. In some cases, it is possible to adjust the egg collection time.

When to avoid using a trigger shot?

Doctors often inform pregnant couples in advance about the possible side effects of trigger injections for ovulation. Trigger injections for ovulation are not recommended for women with primary ovarian failure or poor ovarian reserves. If your doctor believes that you are at risk of developing OHSS, they may not suggest trigger shots. The chances of developing OHSS are greater in the following circumstances

  • Moderate to severe OHSS symptoms experienced during any of the infertility treatment cycles.
  • High estrogen levels before the scheduled time for injections.
  • The ovaries overreact to fertility drugs and the ovaries have produced too many follicles.
  • Any prior allergies to Ovidrel or injectable hCG trigger shot Fertility side effects

Doctors also cancel the fertility treatment cycle if the reports of hormonal blood and ultrasounds of the ovaries do not seem encouraging or promising.

Should You Use a Trigger Shot If You Have PCOS?

Polycystic ovary syndrome is a common hormonal problem in many women today. Women with PCOS are at high risk of developing ovarian hyperstimulation syndrome (OHSS). 

This does not mean that women with PCOS cannot receive trigger or Ovidrel injections. Ovidrel is a commonly used drug for fertility treatments in women with PCOS. But it should be given after consulting with a doctor.

Trigger shot and pregnancy odds

The trigger shots generally stimulate ovulation within 24 to 36 hours after it is given. If you are taking trigger shots for infertility as part of scheduled sexual intercourse, doctors strongly recommend having sex the same night the shots was given.

Doctors also suggest that couples have sex every night for the next two to three days. But if the trigger injections for fertility are part of a structured IUI or IVF cycle, then your doctor will give you the specific time to come to the clinic. The timing of the trigger will decide the optimal time for your visit.

The success and chances of pregnancy when a trigger shot is given depend on several factors. Success rates will vary depending on the prognosis of the medical problem, medical history, age, and the type of fertility treatment chosen.

Studies and data have compared whether trigger shots during an IUI cycle is higher compared to cycles in which the shots were given based on the body’s natural LH surge.

Studies showed that the use of trigger shots increased the chances of pregnancy, especially when programmed to map the natural surge of LH in the body. According to the data, the chances of pregnancy are as follows:

  • 18% positive overall
  • 18% positive for those who took a shot of r-hCG trigger shot
  • 6% positive for those who did not receive an r-hCG trigger shots
  • 31% for those who took the r-hCG trigger shots in sync with their body’s natural surge of LH

Trigger shots for infertility can increase the chances of pregnancy, but the timing of it is the most important thing. 

If you are considering this as one of the options to improve your fertility, you should discuss the same with your doctor. Your doctor will be better able to guide you on fertility treatments and give you clear advice on what you can do to improve your chances of getting pregnant. However, the safest and effective is Home Insemination.

Home Insemination: The Ultimate Solution

Home insemination is a strategy that could help deal with a specific type of inability to conceive in both men and women. In this treatment, sperm are placed directly into a woman’s cervix, fallopian tubes, or uterus.

This makes the journey much shorter for the sperm and also avoids any doable blockage. Preferably, it enables motherhood where it had not been before. Intrauterine insemination (IUI), where sperm is placed in the uterus, is one of the most typical types of home insemination.


Maternity prices for women doing synthetic insemination might not be as high as they are for some even more innovative methods, this method has some essential benefits: it is an easy treatment with a couple of side impacts and it is also inexpensive.

Women with “non-receptive cervical mucosa” also have great prospects for home insemination. In these women, the mucosa that lines the cervix is ​​aggressive to sperm and prevents sperm from getting involved in the uterus and fallopian tubes. Home insemination allows the sperm to completely lose the cervical mucosa. Doctors also commonly recommend home insemination when they cannot find the justification for a couple to be sterile.

Home insemination kits can be used for many types of fertility problems. The inability to conceive of therapy is preferable for men who have extremely low numbers of sperm or sperm that are not normally strong enough to swim with the cervix and even the fallopian tubes. Home insemination is also occasionally an alternative for women who have endometriosis or irregularities in any of their organs in the procreative body. 


How effective is home insemination at home? 

The effectiveness rate is slightly lower than what would happen with natural intercourse. For example, anecdotal evidence shows that the chances of getting pregnant with home insemination at home are around ten to fifteen per cent per ovulation, while with natural intercourse the chances are much higher, between twenty and thirty per cent. hundred.

The sperm can be from your partner or from an unknown donor. Sperm banks are the best option for the latter since they keep specific and clear records on the donor’s genetics, the quality of the sperm, etc. Be sure to use a legal agreement when extracting sperm from someone you know, in case only you want rights to the baby.


Home insemination kit is an excellent option for many women thanks to the comfort, convenience, and low cost it offers which is way easier and not complicated than trigger shots.


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